Phosphagen kinase function in flagellated spores of the oomycete Phytophthora infestans integrates transcriptional regulation, metabolic dynamics and protein retargeting.
Identifieur interne : 000704 ( Main/Exploration ); précédent : 000703; suivant : 000705Phosphagen kinase function in flagellated spores of the oomycete Phytophthora infestans integrates transcriptional regulation, metabolic dynamics and protein retargeting.
Auteurs : Meenakshi S. Kagda [États-Unis] ; Andrea L. Vu [États-Unis] ; Audrey M V. Ah-Fong [États-Unis] ; Howard S. Judelson [États-Unis]Source :
- Molecular microbiology [ 1365-2958 ] ; 2018.
Descripteurs français
- KwdFr :
- Adénosine triphosphate (métabolisme), Animaux (MeSH), Cytoplasme (enzymologie), Flagelles (enzymologie), Lycopersicon esculentum (génétique), Lycopersicon esculentum (parasitologie), Mitochondries (métabolisme), Phosphotransferases (génétique), Phosphotransferases (métabolisme), Phytophthora infestans (enzymologie), Phytophthora infestans (génétique), Régulation de l'expression des gènes (physiologie), Sporanges (enzymologie), Spores (enzymologie), Taurine (analogues et dérivés), Taurine (métabolisme).
- MESH :
- analogues et dérivés : Taurine.
- enzymologie : Cytoplasme, Flagelles, Phytophthora infestans, Sporanges, Spores.
- génétique : Lycopersicon esculentum, Phosphotransferases, Phytophthora infestans.
- métabolisme : Adénosine triphosphate, Mitochondries, Phosphotransferases, Taurine.
- parasitologie : Lycopersicon esculentum.
- physiologie : Régulation de l'expression des gènes.
- Animaux.
English descriptors
- KwdEn :
- Adenosine Triphosphate (metabolism), Animals (MeSH), Cytoplasm (enzymology), Flagella (enzymology), Gene Expression Regulation (physiology), Lycopersicon esculentum (genetics), Lycopersicon esculentum (parasitology), Mitochondria (metabolism), Phosphotransferases (genetics), Phosphotransferases (metabolism), Phytophthora infestans (enzymology), Phytophthora infestans (genetics), Sporangia (enzymology), Spores (enzymology), Taurine (analogs & derivatives), Taurine (metabolism).
- MESH :
- chemical , analogs & derivatives : Taurine.
- chemical , genetics : Phosphotransferases.
- chemical , metabolism : Adenosine Triphosphate, Phosphotransferases, Taurine.
- enzymology : Cytoplasm, Flagella, Phytophthora infestans, Sporangia, Spores.
- genetics : Lycopersicon esculentum, Phytophthora infestans.
- metabolism : Mitochondria.
- parasitology : Lycopersicon esculentum.
- physiology : Gene Expression Regulation.
- Animals.
Abstract
Flagellated spores play important roles in the infection of plants and animals by many eukaryotic microbes. The oomycete Phytophthora infestans, which causes potato blight, expresses two phosphagen kinases (PKs). These enzymes store energy in taurocyamine, and are hypothesized to resolve spatial and temporal imbalances between rates of ATP creation and use in zoospores. A dimeric PK is found at low levels in vegetative mycelia, but high levels in ungerminated sporangia and zoospores. In contrast, a monomeric PK protein is at similar levels in all tissues, although is transcribed primarily in mycelia. Subcellular localization studies indicate that the monomeric PK is mitochondrial. In contrast, the dimeric PK is cytoplasmic in mycelia and sporangia but is retargeted to flagellar axonemes during zoosporogenesis. This supports a model in which PKs shuttle energy from mitochondria to and through flagella. Metabolite analysis indicates that deployment of the flagellar PK is coordinated with a large increase in taurocyamine, synthesized by sporulation-induced enzymes that were lost during the evolution of zoospore-lacking oomycetes. Thus, PK function is enabled by coordination of the transcriptional, metabolic and protein targeting machinery during the life cycle. Since plants lack PKs, the enzymes may be useful targets for inhibitors of oomycete plant pathogens.
DOI: 10.1111/mmi.14108
PubMed: 30137656
Affiliations:
Links toward previous steps (curation, corpus...)
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Kagda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521</wicri:regionArea><wicri:noRegion>92521</wicri:noRegion></affiliation></author><author><name sortKey="Vu, Andrea L" sort="Vu, Andrea L" uniqKey="Vu A" first="Andrea L" last="Vu">Andrea L. Vu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521</wicri:regionArea><wicri:noRegion>92521</wicri:noRegion></affiliation></author><author><name sortKey="Ah Fong, Audrey M V" sort="Ah Fong, Audrey M V" uniqKey="Ah Fong A" first="Audrey M V" last="Ah-Fong">Audrey M V. Ah-Fong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521</wicri:regionArea><wicri:noRegion>92521</wicri:noRegion></affiliation></author><author><name sortKey="Judelson, Howard S" sort="Judelson, Howard S" uniqKey="Judelson H" first="Howard S" last="Judelson">Howard S. Judelson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521</wicri:regionArea><wicri:noRegion>92521</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular microbiology</title><idno type="eISSN">1365-2958</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Triphosphate (metabolism)</term><term>Animals (MeSH)</term><term>Cytoplasm (enzymology)</term><term>Flagella (enzymology)</term><term>Gene Expression Regulation (physiology)</term><term>Lycopersicon esculentum (genetics)</term><term>Lycopersicon esculentum (parasitology)</term><term>Mitochondria (metabolism)</term><term>Phosphotransferases (genetics)</term><term>Phosphotransferases (metabolism)</term><term>Phytophthora infestans (enzymology)</term><term>Phytophthora infestans (genetics)</term><term>Sporangia (enzymology)</term><term>Spores (enzymology)</term><term>Taurine (analogs & derivatives)</term><term>Taurine (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine triphosphate (métabolisme)</term><term>Animaux (MeSH)</term><term>Cytoplasme (enzymologie)</term><term>Flagelles (enzymologie)</term><term>Lycopersicon esculentum (génétique)</term><term>Lycopersicon esculentum (parasitologie)</term><term>Mitochondries (métabolisme)</term><term>Phosphotransferases (génétique)</term><term>Phosphotransferases (métabolisme)</term><term>Phytophthora infestans (enzymologie)</term><term>Phytophthora infestans (génétique)</term><term>Régulation de l'expression des gènes (physiologie)</term><term>Sporanges (enzymologie)</term><term>Spores (enzymologie)</term><term>Taurine (analogues et dérivés)</term><term>Taurine (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Taurine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Phosphotransferases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Triphosphate</term><term>Phosphotransferases</term><term>Taurine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Taurine</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Cytoplasme</term><term>Flagelles</term><term>Phytophthora infestans</term><term>Sporanges</term><term>Spores</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Cytoplasm</term><term>Flagella</term><term>Phytophthora infestans</term><term>Sporangia</term><term>Spores</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lycopersicon esculentum</term><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Lycopersicon esculentum</term><term>Phosphotransferases</term><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine triphosphate</term><term>Mitochondries</term><term>Phosphotransferases</term><term>Taurine</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Lycopersicon esculentum</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Lycopersicon esculentum</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Régulation de l'expression des gènes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Flagellated spores play important roles in the infection of plants and animals by many eukaryotic microbes. The oomycete Phytophthora infestans, which causes potato blight, expresses two phosphagen kinases (PKs). These enzymes store energy in taurocyamine, and are hypothesized to resolve spatial and temporal imbalances between rates of ATP creation and use in zoospores. A dimeric PK is found at low levels in vegetative mycelia, but high levels in ungerminated sporangia and zoospores. In contrast, a monomeric PK protein is at similar levels in all tissues, although is transcribed primarily in mycelia. Subcellular localization studies indicate that the monomeric PK is mitochondrial. In contrast, the dimeric PK is cytoplasmic in mycelia and sporangia but is retargeted to flagellar axonemes during zoosporogenesis. This supports a model in which PKs shuttle energy from mitochondria to and through flagella. Metabolite analysis indicates that deployment of the flagellar PK is coordinated with a large increase in taurocyamine, synthesized by sporulation-induced enzymes that were lost during the evolution of zoospore-lacking oomycetes. Thus, PK function is enabled by coordination of the transcriptional, metabolic and protein targeting machinery during the life cycle. Since plants lack PKs, the enzymes may be useful targets for inhibitors of oomycete plant pathogens.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30137656</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>09</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2958</ISSN><JournalIssue CitedMedium="Internet"><Volume>110</Volume><Issue>2</Issue><PubDate><Year>2018</Year><Month>10</Month></PubDate></JournalIssue><Title>Molecular microbiology</Title><ISOAbbreviation>Mol Microbiol</ISOAbbreviation></Journal><ArticleTitle>Phosphagen kinase function in flagellated spores of the oomycete Phytophthora infestans integrates transcriptional regulation, metabolic dynamics and protein retargeting.</ArticleTitle><Pagination><MedlinePgn>296-308</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/mmi.14108</ELocationID><Abstract><AbstractText>Flagellated spores play important roles in the infection of plants and animals by many eukaryotic microbes. The oomycete Phytophthora infestans, which causes potato blight, expresses two phosphagen kinases (PKs). These enzymes store energy in taurocyamine, and are hypothesized to resolve spatial and temporal imbalances between rates of ATP creation and use in zoospores. A dimeric PK is found at low levels in vegetative mycelia, but high levels in ungerminated sporangia and zoospores. In contrast, a monomeric PK protein is at similar levels in all tissues, although is transcribed primarily in mycelia. Subcellular localization studies indicate that the monomeric PK is mitochondrial. In contrast, the dimeric PK is cytoplasmic in mycelia and sporangia but is retargeted to flagellar axonemes during zoosporogenesis. This supports a model in which PKs shuttle energy from mitochondria to and through flagella. Metabolite analysis indicates that deployment of the flagellar PK is coordinated with a large increase in taurocyamine, synthesized by sporulation-induced enzymes that were lost during the evolution of zoospore-lacking oomycetes. Thus, PK function is enabled by coordination of the transcriptional, metabolic and protein targeting machinery during the life cycle. Since plants lack PKs, the enzymes may be useful targets for inhibitors of oomycete plant pathogens.</AbstractText><CopyrightInformation>© 2018 John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kagda</LastName><ForeName>Meenakshi S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vu</LastName><ForeName>Andrea L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ah-Fong</LastName><ForeName>Audrey M V</ForeName><Initials>AMV</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Judelson</LastName><ForeName>Howard S</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Plant Pathology, University of California, Riverside, CA, 92521, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>10</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol Microbiol</MedlineTA><NlmUniqueID>8712028</NlmUniqueID><ISSNLinking>0950-382X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>1EQV5MLY3D</RegistryNumber><NameOfSubstance UI="D013654">Taurine</NameOfSubstance></Chemical><Chemical><RegistryNumber>543-18-0</RegistryNumber><NameOfSubstance UI="C009558">taurocyamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>8L70Q75FXE</RegistryNumber><NameOfSubstance UI="D000255">Adenosine Triphosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.-</RegistryNumber><NameOfSubstance UI="D010770">Phosphotransferases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000255" MajorTopicYN="N">Adenosine Triphosphate</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003593" MajorTopicYN="N">Cytoplasm</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005407" MajorTopicYN="N">Flagella</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018551" MajorTopicYN="N">Lycopersicon esculentum</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010770" MajorTopicYN="N">Phosphotransferases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055750" MajorTopicYN="N">Phytophthora infestans</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058432" MajorTopicYN="N">Sporangia</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013170" MajorTopicYN="N">Spores</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013654" MajorTopicYN="N">Taurine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>08</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30137656</ArticleId><ArticleId IdType="doi">10.1111/mmi.14108</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kagda, Meenakshi S" sort="Kagda, Meenakshi S" uniqKey="Kagda M" first="Meenakshi S" last="Kagda">Meenakshi S. Kagda</name></noRegion><name sortKey="Ah Fong, Audrey M V" sort="Ah Fong, Audrey M V" uniqKey="Ah Fong A" first="Audrey M V" last="Ah-Fong">Audrey M V. Ah-Fong</name><name sortKey="Judelson, Howard S" sort="Judelson, Howard S" uniqKey="Judelson H" first="Howard S" last="Judelson">Howard S. Judelson</name><name sortKey="Vu, Andrea L" sort="Vu, Andrea L" uniqKey="Vu A" first="Andrea L" last="Vu">Andrea L. Vu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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